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名稱	Recombinant Human IL-17 （IL-17A）
型號
更新時間	2023-09-24
特點	重組IL-17蛋白質,現(xiàn)在被稱為IL-17A,是136為兩個氨基酸鏈,激活t細胞,分泌的促炎和造血基質細胞誘導生產生物活性分子。重組人類IL-17A 31.3 kDa disulfide-linked為兩個137氨基酸的多肽鏈。使用所有無動物生產試劑。}

詳細內容

一.產品名稱：Recombinant Human IL-17 (IL-17A)/Peprotech IL-17

二.Catalog Number:AF-200-17

三.Synonyms:IL-17, CTLA-8

四.Description:

The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains. Manufactured using all non-animal reagents.

五.AA Sequence:

MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:Measured by its ability to induce IL-6 production by NHDF cells using a concentration range of 0.5-1.5 ng/ml.

九.Cross Reactivity:Human, Cow