| 名稱 | Recombinant Human PDGF-BB |
| 型號(hào) | |
| 更新時(shí)間 | 2023-09-24 |
| 特點(diǎn) | PDGFs disulfide-linked二聚體由兩個(gè)12.0 - -13.5 kDa多肽鏈,三個(gè)天然PDGFs;PDGF-AA PDGF-BB PDGF-AB,是強(qiáng)有力的mitogens平滑肌細(xì)胞等多種細(xì)胞類(lèi)型,結(jié)締組織細(xì)胞,骨和軟骨細(xì)胞,和一些血液細(xì)胞。PDGFs參與的生物學(xué)過(guò)程,包括增生、趨化性、胚胎神經(jīng)元發(fā)展,呼吸道小管上皮細(xì)胞的發(fā)展。} |
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一.產(chǎn)品名稱：Recombinant Human PDGF-BB/Peprotech PDGF-BB
二.Catalog Number:AF-100-14B
三.Synonyms:
Plaet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF)
四.Description:
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in plaet α-granules and are released upon plaet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). . Manufactured using all non-animal reagents.
五.AA Sequence:
SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT
六.Source:E.coli
七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
八.Biological Activity:
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 1.0-3.0 ng/ml.
九.Cross Reactivity:Cow, Monkey, Mouse, Pig, Rat, Human
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電話/傳真：13366128764
手機(jī)：15311648455
地址：北京市海淀區(qū)廂黃旗2號(hào)樓1層4-179室